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apalutamide will lower the extent or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with prescription drugs that happen to be CYP2C19 substrates may end up in reduce exposure to those drugs.diazepam will raise the level or effect of